The most common symptoms in patients with pancreatitis due to PHPT are abdominal pain and vomiting, which were also observed in our patient. Although hypocalcaemia may present in patients with severe acute pancreatitis, hypercalcaemia is still an important clue for the diagnosis of PHPT. When we excluded the other aetiologies of acute pancreatitis, the patient was diagnosed with PHPT-induced acute necrotizing pancreatitis.
Only a few cases have been reported [ 14 , 21 ]. There is no consensus on the treatment of PHPT-induced pancreatitis during pregnancy. Parathyroidectomy is the only curative treatment and is recommended when calcium levels are above 2. The optimal time for surgery has been considered to be the second trimester.
Following the parathyroidectomy, the foetus was normal, and the patient was eucalcaemic and had normal PTH levels; however, the patient died of multiple organ failure due to severe pancreatitis. In conclusion, although PHPT-induced acute pancreatitis is very rare and most patients have mild hypercalcaemia or are asymptomatic, serious complications may have catastrophic consequences for both the mother and the foetus.
Diagnosis and treatment can be challenging, and severe complications are life threatening. Our case indicates that early diagnosis and appropriate management may reduce maternal and foetal mortality. The datasets supporting the conclusions of this article is included within the article and in figures. Bilezikian JP. Primary hyperparathyroidism. J Clin Endocrinol Metab. Article Google Scholar. Incidence and prevalence of primary hyperparathyroidism in a racially mixed population.
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It furthers the University's objective of excellence in research, scholarship, and education by publishing worldwide. Sign In or Create an Account. Sign In. Advanced Search. Search Menu. Article Navigation. Close mobile search navigation Article Navigation. Volume Article Contents Abstract. Patients and Methods. Oxford Academic. Santhi Swaroop Vege. Haitham S. Euijung Ryu. Sarah Nadeem. Robert A. Select Format Select format. Permissions Icon Permissions.
TABLE 1. Total PHPT. Open in new tab. TABLE 2. Patient no. Age yr , a gender. Coronavirus Resource Center. Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy Continue.
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